By Leopold G. Koss and Dulcie V. Coleman (Auth.)

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Both Isaacs and An-Foraker have found the diagnostic accuracy of endometrial aspiration techniques very satis­ factory. They have examined large series of patients, many of whom had pathological lesions of the uterus. A multicentre trial is currently being organized in the UK in order to obtain co-ordinated opinion as to the efficiency of the Isaacs aspirator in this respect. 2 are several. The need to make a definitive diagnosis on each aspirate is good cytological discipline and assists in establishing criteria for diagnosis.

The nuclei are pale, 52 The value of endometrial aspiration in gynaecological practice basophilic and regular in size and shape, and are well separated by pale indistinct cytoplasm. The chromatin structure is often ill-defined, but if discernible is fine and regular. The background is relatively free of debris and red blood cells (see Plate 4). Cyclical pattern Endometrial cells shed from endometrium of premenopausal women with a normal menstrual cycle are shown in Plates 5 and 6. The nuclei are regular in size and shape, and appear round or oval with fine granular chromatin structure sometimes with small chromocentres.

And GELFAND, M. M. (1979) Studies on the cytodynamics of human endometrial regeneration. III. In vitro short term incubation historadioautography, American Journal of Obstetrics and Gynecology, 134, 297-304 35. , BERTRAND, G. and GELFAND, M. M. (1979) Proliferation kinetics of human endometrium during the normal menstrual cycle, American Journal of Obstetrics and Gynecology, 133, 859-867 36. HENZL, M. , SMITH, R. , BOOST, G. a n d TYLER, E. T. ( 1 9 7 2 ) 37. 38. 39. 40. 41. 42. Lysosomal concept of menstrual bleeding in humans, Journal of Clinical Endocrinology and Metabolism, 34, 860-875 GORSKI, J.

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