By Yang Xia

This special booklet describes the newest details within the basic figuring out of the biophysics and biochemistry of articular cartilage utilizing the state of the art practices in NMR and MRI. this can be the 1st e-book of its type, written via physicists and chemists in this very important tissue, whose degradation contributes to osteoarthritis and comparable joint ailments. Connecting the elemental technology with the medical imaging purposes, the specialists Editors offer an authoritative addition to the literature.
Ideal for training actual scientists and radiologists with an curiosity within the basic technological know-how in addition to software brands and medical researchers operating with articular cartilage

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1) is also instrumental for the understanding of anisotropic NMR properties of water and aqueous solutes. Transient association with aligned collagen fibrils can impart a residual alignment order to the aqueous species. This can be manifested in the NMR experiment as anisotropic spin relaxation rates (chapters 4, 5, and 12), residual dipolar or quadrupolar coupling constants (chapters 8 and 9), or anisotropic diffusivities (chapters 7, 14, and 22). 4 Other Components Besides the three major components, the cartilage ECM contains numerous minor components.

The lines represent the orientation of the collagen fibers; the ovals represent the chondrocytes in cartilage (not to scale). S: superficial zone; T: transitional zone; R: radial zone; CC: calcified cartilage; BM: bone marrow space. cartilage) to approximately 4 mm (human knee). 16 Histologically, articular cartilage is commonly subdivided into four distinct and parallel zones based on the local orientation of the collagen fibrils. 2). 1039/9781782623663-00001 articular cartilage over the lifetime.

3) Through deformation, articular cartilage distributes the forces exerted on the bone to a greater contact area. Known as load processing, this reduces contact stresses between the bones and protects the bones from fatigue. Because of the unique molecular and morphological structures of articular cartilage, the biomechanical properties of cartilage in joints are both poroviscoelastic and depth-dependent. 4b). g. ion) cannot be without a counter-charge for an extended period, and causes counter-ions and co-ions, namely Na+ and Cl−, to be pulled into the tissue.

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